diff --git a/src/mumble/GlobalShortcut.cpp b/src/mumble/GlobalShortcut.cpp
index ab540cf68d8..0dae14e39ba 100644
--- a/src/mumble/GlobalShortcut.cpp
+++ b/src/mumble/GlobalShortcut.cpp
@@ -9,6 +9,7 @@
 #include "Channel.h"
 #include "ClientUser.h"
 #include "Database.h"
+#include "EnvUtils.h"
 #include "MainWindow.h"
 #include "Global.h"
 #include "GlobalShortcutButtons.h"
@@ -525,6 +526,16 @@ GlobalShortcutConfig::GlobalShortcutConfig(Settings &st) : ConfigWidget(st) {
 
 	qcbEnableGlobalShortcuts->setVisible(canDisable);
 
+	qlWaylandNote->setVisible(false);
+#ifdef Q_OS_LINUX
+	if (EnvUtils::waylandIsUsed()) {
+		// Our global shortcut system doesn't work with Wayland
+		qlWaylandNote->setVisible(true);
+
+		qgbShortcuts->setEnabled(false);
+	}
+#endif
+
 #ifdef Q_OS_MAC
 	// Help Mac users enable accessibility access for Mumble...
 #	if QT_VERSION >= QT_VERSION_CHECK(5, 9, 0)
@@ -750,6 +761,7 @@ QTreeWidgetItem *GlobalShortcutConfig::itemForShortcut(const Shortcut &sc) const
 void GlobalShortcutConfig::reload() {
 	std::stable_sort(qlShortcuts.begin(), qlShortcuts.end());
 	qtwShortcuts->clear();
+
 	foreach (const Shortcut &sc, qlShortcuts) {
 		QTreeWidgetItem *item = itemForShortcut(sc);
 		qtwShortcuts->addTopLevelItem(item);
diff --git a/src/mumble/GlobalShortcut.ui b/src/mumble/GlobalShortcut.ui
index e2796c53ec7..af65a45c1a9 100644
--- a/src/mumble/GlobalShortcut.ui
+++ b/src/mumble/GlobalShortcut.ui
@@ -95,6 +95,19 @@
      </layout>
     </widget>
    </item>
+   <item>
+    <widget class="QLabel" name="qlWaylandNote">
+     <property name="text">
+      <string>&lt;html&gt;&lt;head/&gt;&lt;body&gt;&lt;p&gt;Mumble's Global Shortcuts system does currently not work in combination with the Wayland protocol. For more information, visit &lt;a href=&quot;https://github.com/mumble-voip/mumble/issues/5257&quot;&gt;&lt;span style=&quot; text-decoration: underline; color:#0057ae;&quot;&gt;https://github.com/mumble-voip/mumble/issues/5257&lt;/span&gt;&lt;/a&gt;.&lt;/p&gt;&lt;/body&gt;&lt;/html&gt;</string>
+     </property>
+     <property name="wordWrap">
+      <bool>true</bool>
+     </property>
+     <property name="openExternalLinks">
+      <bool>true</bool>
+     </property>
+    </widget>
+   </item>
    <item>
     <widget class="QGroupBox" name="qgbShortcuts">
      <property name="title">
diff --git a/src/mumble/GlobalShortcut_unix.cpp b/src/mumble/GlobalShortcut_unix.cpp
index 9c56bb616e7..af63d32900e 100644
--- a/src/mumble/GlobalShortcut_unix.cpp
+++ b/src/mumble/GlobalShortcut_unix.cpp
@@ -5,6 +5,7 @@
 
 #include "GlobalShortcut_unix.h"
 
+#include "EnvUtils.h"
 #include "Settings.h"
 #include "Global.h"
 
@@ -62,6 +63,11 @@ GlobalShortcutX::GlobalShortcutX() {
 	}
 
 #ifdef Q_OS_LINUX
+	if (EnvUtils::waylandIsUsed()) {
+		qWarning("GlobalShortcutX: Global shortcuts don't work on Wayland (see https://github.com/mumble-voip/mumble/issues/5257)");
+		return;
+	}
+
 	if (Global::get().s.bEnableEvdev) {
 		QString dir             = QLatin1String("/dev/input");
 		QFileSystemWatcher *fsw = new QFileSystemWatcher(QStringList(dir), this);
diff --git a/src/mumble/Settings.cpp b/src/mumble/Settings.cpp
index 475e5eea4b0..86650c099ae 100644
--- a/src/mumble/Settings.cpp
+++ b/src/mumble/Settings.cpp
@@ -7,6 +7,7 @@
 
 #include "AudioInput.h"
 #include "Cert.h"
+#include "EnvUtils.h"
 #include "Log.h"
 #include "SSL.h"
 #include "Global.h"
@@ -532,6 +533,12 @@ Settings::Settings() {
 	bEnableXboxInput            = true;
 	bEnableUIAccess             = true;
 
+#ifdef Q_OS_LINUX
+	if (EnvUtils::waylandIsUsed()) {
+		bShortcutEnable = false;
+	}
+#endif
+
 	for (int i = Log::firstMsgType; i <= Log::lastMsgType; ++i) {
 		qmMessages.insert(i,
 						  Settings::LogConsole | Settings::LogBalloon | Settings::LogTTS | Settings::LogMessageLimit);
@@ -1007,6 +1014,13 @@ void Settings::load(QSettings *settings_ptr) {
 	LOAD(bEnableXboxInput, "shortcut/windows/xbox/enable");
 	LOAD(bEnableUIAccess, "shortcut/windows/uiaccess/enable");
 
+#ifdef Q_OS_LINUX
+	if (EnvUtils::waylandIsUsed()) {
+		// Global shortcuts don't work on Wayland
+		bShortcutEnable = false;
+	}
+#endif
+
 	// Search options
 	LOAD(searchForUsers, "search/search_for_users");
 	LOAD(searchForChannels, "search/search_for_channels");