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Pixel-Lesion-pAtient Network (PLAN)

This is the code for Pixel-Lesion-pAtient Network (PLAN), a lesion segmentation and classification network for 3D medical images. It combines traditional pixel-level semantic segmentation, object(lesion)-level instance segmentation, and patient-level image classification into one end-to-end network. Please see our paper:

  • Ke Yan, Xiaoli Yin, Yingda Xia, Fakai Wang, Shu Wang, Yuan Gao, Jiawen Yao, Chunli Li, Xiaoyu Bai, Jingren Zhou, Ling Zhang, Le Lu, Yu Shi, "Liver Tumor Screening and Diagnosis in CT with Pixel-Lesion-Patient Network," International Conference on Medical Image Computing & Computer Assisted Intervention (MICCAI), 2023 (arXiv).

framework

This repo is based on the original nnUNet v1. It also borrows from MaskFormer and Mask2Former.

The code is designed for the liver tumor segmentation and classification task in NC and DCE CT. But you can also modify the dataloader and configs to accommodate other single/multi-modality segmentation tasks. I hope to make the project more configurable and flexible for extension.

Features

  • Support original nnUNet, 3D Mask2Former, and PLAN, see nnunet/network_architecture.
  • You can easily specify all hyper-parameters in config files, including folders, gpu, data, data loader, trainer, network, optimizer, validation folders, etc. We provided some examples in configs/.
  • I carefully wrote the post-processing code and evaluation code for lesion segmentation. It can generate segmentation mask and patient-level results during inference. Pixel-level (segmentation), lesion-level (detection), and patient-level (multi-label classification) accuracy will be thoroughly computed. A case report recording accuracy of each case will also be generated.
  • The whole process of training, testing, and evaluation can be run in one line e.g. python main.py --cfg nc_plan1.

Usage

  1. Build a virtual environment with Python 3.
  2. Step into the project folder and install by pip install -e ..
  3. Prepare data, please refer to nnunet/dataset_conversion/my_dataset_prepare.py. It is also helpful to read the documents of nnUNet v1.
  4. Use nnUNet's preprocess command to preprocess data and generate training plan:
UNet_plan_and_preprocess -t XXX -pl2d None

task_id can be any number. This process takes a while. Make sure your disk has enough space (>10G at least) because this step will produce large processed files. It will also produce a 5-fold split file.

  • Modify parameters in config files, e.g. exp_name and results_dir. Modify cfg.mode depending on whether you want to train / continue training / inference / compute accuracy.
  • python nnunet/run/main.py --cfg <config_file>. An example of config_file is nc_plan1, which corresponds to the filename cfg_nc_plan1.py.
  • The training code will train and validate on fold cfg.fold for cfg.optimizer.max_num_epochs epochs. Validation in each epoch is only conducted on some random patches. When training is complete, it will validate on all validation folders specified in cfg.validation.folders. Then it will run evaluation and compute accuracy, see parameters in cfg.validation.

Important files

  • panoSegTrainer is the trainer class I am using.
  • Configs are in configs/, each file is an experiment config. cfg_default.py stores default configs that will be overwritten by other configs.
  • Dataset classes are in nnunet/training/dataloading.
  • Post-processing is in nnunet/inference/post_process.py.
  • Evaluation of differential diagnosis accuracy is in nnunet/evaluation/evaluation_diagnosis.py, while evaluation of lesion screening is in evaluation_screening.py.

My email: [email protected]