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DESCRIPTION
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Type: Package
Package: DoubletFinder
Title: DoubletFinder is a suite of tools for identifying doublets
in single-cell RNA sequencing data
Version: 2.0.4
Author: person("Chris", "McGinnis", email =
"[email protected]", role = c("aut","cre"))
Maintainer: <[email protected]>
Description: DoubletFinder identifies doublets by generating
artificial doublets from existing scRNA-seq data and defining which
real cells preferentially co-localize with artificial doublets in gene
expression space. Other DoubletFinder package functions are used for
fitting DoubletFinder to different scRNA-seq datasets. For example,
ideal DoubletFinder performance in real-world contexts requires (I)
Optimal pK selection and (2) Homotypic doublet proportion estimation.
pK selection is achieved using pN-pK parameter sweeps and maxima
identification in mean-variance-normalized bimodality coefficient
distributions. Homotypic doublet proportion estimation is achieved by
finding the sum of squared cell annotation frequencies. For more
information, see our Cell Sysmtes paper
https://www.cell.com/cell-systems/fulltext/S2405-4712(19)30073-0 and
our github https://github.com/chris-mcginnis-ucsf/DoubletFinder.
License: CC0
Depends:
R (>= 4.0.0)
Imports:
fields,
KernSmooth,
parallel,
ROCR,
Seurat,
SeuratObject
Suggests:
testthat
Encoding: UTF-8
LazyData: true
RoxygenNote: 7.3.2