diff --git a/libs/langgraph/langgraph/utils/config.py b/libs/langgraph/langgraph/utils/config.py
index 5bff9e848..0712b55cf 100644
--- a/libs/langgraph/langgraph/utils/config.py
+++ b/libs/langgraph/langgraph/utils/config.py
@@ -250,6 +250,13 @@ def get_async_callback_manager_for_config(
         )
 
 
+def _is_not_empty(value: Any) -> bool:
+    if isinstance(value, (list, tuple, dict)):
+        return len(value) > 0
+    else:
+        return value is not None
+
+
 def ensure_config(*configs: Optional[RunnableConfig]) -> RunnableConfig:
     """Ensure that a config is a dict with all keys present.
 
@@ -272,20 +279,20 @@ def ensure_config(*configs: Optional[RunnableConfig]) -> RunnableConfig:
             {
                 k: v.copy() if k in COPIABLE_KEYS else v  # type: ignore[attr-defined]
                 for k, v in var_config.items()
-                if v is not None
+                if _is_not_empty(v)
             },
         )
     for config in configs:
         if config is None:
             continue
         for k, v in config.items():
-            if v is not None and k in CONFIG_KEYS:
+            if _is_not_empty(v) and k in CONFIG_KEYS:
                 if k == CONF:
                     empty[k] = cast(dict, v).copy()
                 else:
                     empty[k] = v  # type: ignore[literal-required]
         for k, v in config.items():
-            if v is not None and k not in CONFIG_KEYS:
+            if _is_not_empty(v) and k not in CONFIG_KEYS:
                 empty[CONF][k] = v
     for key, value in empty[CONF].items():
         if (
diff --git a/libs/langgraph/tests/test_utils.py b/libs/langgraph/tests/test_utils.py
index e77cbd3a2..8c9e304c9 100644
--- a/libs/langgraph/tests/test_utils.py
+++ b/libs/langgraph/tests/test_utils.py
@@ -20,6 +20,7 @@
 
 from langgraph.graph import END, StateGraph
 from langgraph.graph.graph import CompiledGraph
+from langgraph.utils.config import _is_not_empty
 from langgraph.utils.fields import (
     _is_optional_type,
     get_enhanced_type_hints,
@@ -284,3 +285,14 @@ class MyPydanticModelWithAnnotated(BaseModel):
     assert hints[0] == ("val_1", str, None, "A description")
     assert hints[1] == ("val_2", int, 42, None)
     assert hints[2] == ("val_3", str, "default", "Another description")
+
+
+def test_is_not_empty() -> None:
+    assert _is_not_empty("foo")
+    assert _is_not_empty("")
+    assert _is_not_empty(1)
+    assert _is_not_empty(0)
+    assert not _is_not_empty(None)
+    assert not _is_not_empty([])
+    assert not _is_not_empty(())
+    assert not _is_not_empty({})