diff --git a/newrelic/config.py b/newrelic/config.py
index 1c3571a546..a447e20bfc 100644
--- a/newrelic/config.py
+++ b/newrelic/config.py
@@ -2540,6 +2540,8 @@ def _process_module_builtin_defaults():
 
     _process_module_definition("uvicorn.config", "newrelic.hooks.adapter_uvicorn", "instrument_uvicorn_config")
 
+    _process_module_definition("daphne.server", "newrelic.hooks.adapter_daphne", "instrument_daphne_server")
+
     _process_module_definition("sanic.app", "newrelic.hooks.framework_sanic", "instrument_sanic_app")
     _process_module_definition("sanic.response", "newrelic.hooks.framework_sanic", "instrument_sanic_response")
 
@@ -2712,7 +2714,9 @@ def _process_module_builtin_defaults():
     )
 
     _process_module_definition(
-        "redis.commands.timeseries.commands", "newrelic.hooks.datastore_redis", "instrument_redis_commands_timeseries_commands"
+        "redis.commands.timeseries.commands",
+        "newrelic.hooks.datastore_redis",
+        "instrument_redis_commands_timeseries_commands",
     )
 
     _process_module_definition(
diff --git a/newrelic/core/environment.py b/newrelic/core/environment.py
index f63047ab5e..17b03813c0 100644
--- a/newrelic/core/environment.py
+++ b/newrelic/core/environment.py
@@ -170,6 +170,13 @@ def environment_settings():
         if hasattr(uvicorn, "__version__"):
             dispatcher.append(("Dispatcher Version", uvicorn.__version__))
 
+    if not dispatcher and "daphne" in sys.modules:
+        dispatcher.append(("Dispatcher", "daphne"))
+        daphne = sys.modules["daphne"]
+
+        if hasattr(daphne, "__version__"):
+            dispatcher.append(("Dispatcher Version", daphne.__version__))
+
     if not dispatcher and "tornado" in sys.modules:
         dispatcher.append(("Dispatcher", "tornado"))
         tornado = sys.modules["tornado"]
diff --git a/newrelic/hooks/adapter_daphne.py b/newrelic/hooks/adapter_daphne.py
new file mode 100644
index 0000000000..430d9c4b3c
--- /dev/null
+++ b/newrelic/hooks/adapter_daphne.py
@@ -0,0 +1,33 @@
+# Copyright 2010 New Relic, Inc.
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#      http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+from newrelic.api.asgi_application import ASGIApplicationWrapper
+
+
+@property
+def application(self):
+    return getattr(self, "_nr_application", vars(self).get("application", None))
+
+
+@application.setter
+def application(self, value):
+    # Wrap app only once
+    if value and not getattr(value, "_nr_wrapped", False):
+        value = ASGIApplicationWrapper(value)
+        value._nr_wrapped = True
+    self._nr_application = value
+
+
+def instrument_daphne_server(module):
+    module.Server.application = application
diff --git a/tests/adapter_daphne/conftest.py b/tests/adapter_daphne/conftest.py
new file mode 100644
index 0000000000..cda62f22e1
--- /dev/null
+++ b/tests/adapter_daphne/conftest.py
@@ -0,0 +1,37 @@
+# Copyright 2010 New Relic, Inc.
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#      http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+from testing_support.fixtures import (  # noqa: F401; pylint: disable=W0611
+    code_coverage_fixture,
+    collector_agent_registration_fixture,
+    collector_available_fixture,
+)
+
+_coverage_source = [
+    "newrelic.hooks.adapter_daphne",
+]
+
+code_coverage = code_coverage_fixture(source=_coverage_source)
+
+_default_settings = {
+    "transaction_tracer.explain_threshold": 0.0,
+    "transaction_tracer.transaction_threshold": 0.0,
+    "transaction_tracer.stack_trace_threshold": 0.0,
+    "debug.log_data_collector_payloads": True,
+    "debug.record_transaction_failure": True,
+}
+
+collector_agent_registration = collector_agent_registration_fixture(
+    app_name="Python Agent Test (adapter_daphne)", default_settings=_default_settings
+)
diff --git a/tests/adapter_daphne/test_daphne.py b/tests/adapter_daphne/test_daphne.py
new file mode 100644
index 0000000000..4953e9a9ff
--- /dev/null
+++ b/tests/adapter_daphne/test_daphne.py
@@ -0,0 +1,136 @@
+# Copyright 2010 New Relic, Inc.
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#      http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import asyncio
+import threading
+from urllib.request import HTTPError, urlopen
+
+import daphne.server
+import pytest
+from testing_support.fixtures import (
+    override_application_settings,
+    raise_background_exceptions,
+    validate_transaction_errors,
+    validate_transaction_metrics,
+    wait_for_background_threads,
+)
+from testing_support.sample_asgi_applications import (
+    AppWithCall,
+    AppWithCallRaw,
+    simple_app_v2_raw,
+)
+from testing_support.util import get_open_port
+
+from newrelic.common.object_names import callable_name
+
+DAPHNE_VERSION = tuple(int(v) for v in daphne.__version__.split(".")[:2])
+skip_asgi_3_unsupported = pytest.mark.skipif(DAPHNE_VERSION < (3, 0), reason="ASGI3 unsupported")
+skip_asgi_2_unsupported = pytest.mark.skipif(DAPHNE_VERSION >= (3, 0), reason="ASGI2 unsupported")
+
+
+@pytest.fixture(
+    params=(
+        pytest.param(
+            simple_app_v2_raw,
+            marks=skip_asgi_2_unsupported,
+        ),
+        pytest.param(
+            AppWithCallRaw(),
+            marks=skip_asgi_3_unsupported,
+        ),
+        pytest.param(
+            AppWithCall(),
+            marks=skip_asgi_3_unsupported,
+        ),
+    ),
+    ids=("raw", "class_with_call", "class_with_call_double_wrapped"),
+)
+def app(request, server_and_port):
+    app = request.param
+    server, _ = server_and_port
+    server.application = app
+    return app
+
+
+@pytest.fixture(scope="session")
+def port(server_and_port):
+    _, port = server_and_port
+    return port
+
+
+@pytest.fixture(scope="session")
+def server_and_port():
+    port = get_open_port()
+
+    servers = []
+    loops = []
+    ready = threading.Event()
+
+    def server_run():
+        def on_ready():
+            if not ready.is_set():
+                loops.append(asyncio.get_event_loop())
+                servers.append(server)
+                ready.set()
+
+        async def fake_app(*args, **kwargs):
+            raise RuntimeError("Failed to swap out app.")
+
+        server = daphne.server.Server(
+            fake_app,
+            endpoints=["tcp:%d:interface=127.0.0.1" % port],
+            ready_callable=on_ready,
+            signal_handlers=False,
+            verbosity=9,
+        )
+
+        server.run()
+
+    thread = threading.Thread(target=server_run, daemon=True)
+    thread.start()
+    assert ready.wait(timeout=10)
+    yield servers[0], port
+
+    reactor = daphne.server.reactor
+    _ = [loop.call_soon_threadsafe(reactor.stop) for loop in loops]  # Stop all loops
+    thread.join(timeout=10)
+
+    if thread.is_alive():
+        raise RuntimeError("Thread failed to exit in time.")
+
+
+@override_application_settings({"transaction_name.naming_scheme": "framework"})
+def test_daphne_200(port, app):
+    @validate_transaction_metrics(callable_name(app))
+    @raise_background_exceptions()
+    @wait_for_background_threads()
+    def response():
+        return urlopen("http://localhost:%d" % port, timeout=10)
+
+    assert response().status == 200
+
+
+@override_application_settings({"transaction_name.naming_scheme": "framework"})
+@validate_transaction_errors(["builtins:ValueError"])
+def test_daphne_500(port, app):
+    @validate_transaction_metrics(callable_name(app))
+    @raise_background_exceptions()
+    @wait_for_background_threads()
+    def _test():
+        try:
+            urlopen("http://localhost:%d/exc" % port)
+        except HTTPError:
+            pass
+
+    _test()
diff --git a/tests/adapter_uvicorn/test_uvicorn.py b/tests/adapter_uvicorn/test_uvicorn.py
index c93e719e84..e3261f4e87 100644
--- a/tests/adapter_uvicorn/test_uvicorn.py
+++ b/tests/adapter_uvicorn/test_uvicorn.py
@@ -97,7 +97,7 @@ async def on_tick():
 
     thread = threading.Thread(target=server_run, daemon=True)
     thread.start()
-    ready.wait()
+    assert ready.wait(timeout=10)
     yield port
     _ = [loop.stop() for loop in loops]  # Stop all loops
     thread.join(timeout=1)
diff --git a/tox.ini b/tox.ini
index 2f7ee4bcce..d054034d2f 100644
--- a/tox.ini
+++ b/tox.ini
@@ -43,6 +43,8 @@
 setupdir = {toxinidir}
 envlist =
     python-adapter_cheroot-{py27,py37,py38,py39,py310},
+    python-adapter_daphne-{py37,py38,py39,py310}-daphnelatest,
+    python-adapter_daphne-py38-daphne{0204,0205},
     python-adapter_gevent-{py27,py37,py38,py310},
     python-adapter_gunicorn-{py37,py38,py39,py310}-aiohttp3-gunicornlatest,
     python-adapter_uvicorn-py37-uvicorn03,
@@ -163,6 +165,9 @@ deps =
 
     # Test Suite Dependencies
     adapter_cheroot: cheroot
+    adapter_daphne-daphnelatest: daphne
+    adapter_daphne-daphne0205: daphne<2.6
+    adapter_daphne-daphne0204: daphne<2.5
     adapter_gevent: WSGIProxy2
     adapter_gevent: gevent
     adapter_gevent: urllib3
@@ -372,6 +377,7 @@ extras =
 
 changedir =
     adapter_cheroot: tests/adapter_cheroot
+    adapter_daphne: tests/adapter_daphne
     adapter_gevent: tests/adapter_gevent
     adapter_gunicorn: tests/adapter_gunicorn
     adapter_uvicorn: tests/adapter_uvicorn