diff --git a/newrelic/hooks/adapter_uvicorn.py b/newrelic/hooks/adapter_uvicorn.py
index b14c663297..ee4a1ab243 100644
--- a/newrelic/hooks/adapter_uvicorn.py
+++ b/newrelic/hooks/adapter_uvicorn.py
@@ -17,6 +17,13 @@
 
 @property
 def loaded_app(self):
+    # Always use the original application until the interface is resolved in
+    # auto mode
+    if getattr(self, "interface", "") == "auto":
+        app = self._nr_loaded_app
+        while hasattr(app, "__wrapped__"):
+            app = app.__wrapped__
+        return app
     return self._nr_loaded_app
 
 
diff --git a/tests/testing_support/sample_asgi_applications.py b/tests/testing_support/sample_asgi_applications.py
index 619ca19214..d8bd523ea1 100644
--- a/tests/testing_support/sample_asgi_applications.py
+++ b/tests/testing_support/sample_asgi_applications.py
@@ -63,6 +63,17 @@ async def static(scope, receive, send):
         return await simple_app_v3_raw(scope, receive, send)
 
 
+class AppWithCallRaw:
+    async def __call__(self, scope, receive, send):
+        return await simple_app_v3_raw(scope, receive, send)
+
+
+class AppWithCall(AppWithCallRaw):
+    @ASGIApplicationWrapper
+    async def __call__(self, scope, receive, send):
+        return await super(AppWithCall, self).__call__(scope, receive, send)
+
+
 simple_app_v2 = ASGIApplicationWrapper(simple_app_v2_raw)
 simple_app_v2_init_exc = ASGIApplicationWrapper(simple_app_v2_init_exc)
 simple_app_v3 = ASGIApplicationWrapper(simple_app_v3_raw)