diff --git a/.Rbuildignore b/.Rbuildignore
index d203ce14f..e2d47f235 100644
--- a/.Rbuildignore
+++ b/.Rbuildignore
@@ -4,7 +4,6 @@
 ^\.Rproj\.user$
 ^.*\.old$
 .git
-appveyor.yml
 cran-comments.md
 CODE_OF_CONDUCT.md
 ^_pkgdown\.yaml$
diff --git a/.github/workflows/integration_checks.yaml b/.github/workflows/integration_checks.yaml
index a8e6e3f86..721225fe0 100644
--- a/.github/workflows/integration_checks.yaml
+++ b/.github/workflows/integration_checks.yaml
@@ -1,16 +1,14 @@
 name: Integration Checks
 
-# Because `develop` is a protected branch this workflow is triggered when a PR 
+# Because `main` is a protected branch this workflow is triggered when a PR 
 # is opened/updated and again when it is merged.
 on:
   push:
-    branches: 
-    - develop
-    - master
+    branches:
+    - main 
   pull_request:
     branches: 
-    - develop
-    - master
+    - main
 
 jobs:
   check-package:
diff --git a/DESCRIPTION b/DESCRIPTION
index e30bbb3a8..99acc584b 100644
--- a/DESCRIPTION
+++ b/DESCRIPTION
@@ -1,5 +1,5 @@
 Package: Seurat
-Version: 5.2.1
+Version: 5.2.99.9000
 Title: Tools for Single Cell Genomics
 Description: A toolkit for quality control, analysis, and exploration of single cell RNA sequencing data. 'Seurat' aims to enable users to identify and interpret sources of heterogeneity from single cell transcriptomic measurements, and to integrate diverse types of single cell data. See Satija R, Farrell J, Gennert D, et al (2015) <doi:10.1038/nbt.3192>, Macosko E, Basu A, Satija R, et al (2015) <doi:10.1016/j.cell.2015.05.002>, Stuart T, Butler A, et al (2019) <doi:10.1016/j.cell.2019.05.031>, and Hao, Hao, et al (2020) <doi:10.1101/2020.10.12.335331> for more details.
 Authors@R: c(
diff --git a/README.md b/README.md
index 56a7e94b1..bda205197 100644
--- a/README.md
+++ b/README.md
@@ -1,4 +1,3 @@
-[![AppVeyor build status](https://ci.appveyor.com/api/projects/status/github/satijalab/seurat?branch=master&svg=true)](https://ci.appveyor.com/project/satijalab/seurat)
 [![CRAN Version](https://www.r-pkg.org/badges/version/Seurat)](https://cran.r-project.org/package=Seurat)
 [![CRAN Downloads](https://cranlogs.r-pkg.org/badges/Seurat)](https://cran.r-project.org/package=Seurat)
 
diff --git a/appveyor.yml b/appveyor.yml
deleted file mode 100644
index 7a987f45a..000000000
--- a/appveyor.yml
+++ /dev/null
@@ -1,62 +0,0 @@
-# DO NOT CHANGE the "init" and "install" sections below
-
-# Download script file from GitHub
-init:
-  ps: |
-        $ErrorActionPreference = "Stop"
-        Invoke-WebRequest http://raw.github.com/krlmlr/r-appveyor/master/scripts/appveyor-tool.ps1 -OutFile "..\appveyor-tool.ps1"
-        Import-Module '..\appveyor-tool.ps1'
-install:
-  - "%PYTHON%\\python.exe -m pip install wheel"
-  - "%PYTHON%\\python.exe -m pip install phate"
-  - ps: Bootstrap
-
-# Adapt as necessary starting from here
-
-environment:
-  global:
-    R_ARCH: x64
-    USE_RTOOLS: true
-    BIOC_USE_DEVEL: "FALSE"
-    _R_CHECK_FORCE_SUGGESTS_: false
-    PYTHON: "C:\\Python36-x64"
-    RETICULATE_PYTHON: "C:\\Python36-x64"
-    CRAN: "https://cloud.r-project.org"
-    R_LIBCURL_SSL_REVOKE_BEST_EFFORT: "TRUE"
-    CURL_SSL_BACKEND: "openssl"
-
-build_script:
-  - travis-tool.sh install_deps
-  - travis-tool.sh r_binary_install curl
-  - travis-tool.sh bioc_install GenomeInfoDbData
-  - travis-tool.sh bioc_install DESeq2
-  - travis-tool.sh bioc_install MAST
-  - travis-tool.sh bioc_install S4Vectors
-  - travis-tool.sh bioc_install SummarizedExperiment
-  - travis-tool.sh bioc_install SingleCellExperiment
-
-test_script:
-  - travis-tool.sh run_tests
-
-on_failure:
-  - 7z a failure.zip *.Rcheck\*
-  - appveyor PushArtifact failure.zip
-
-artifacts:
-  - path: '*.Rcheck\**\*.log'
-    name: Logs
-
-  - path: '*.Rcheck\**\*.out'
-    name: Logs
-
-  - path: '*.Rcheck\**\*.fail'
-    name: Logs
-
-  - path: '*.Rcheck\**\*.Rout'
-    name: Logs
-
-  - path: '\*_*.tar.gz'
-    name: Bits
-
-  - path: '\*_*.zip'
-    name: Bits