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# Instructions | ||
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Calculate the Hamming distance between two DNA strands. | ||
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Your body is made up of cells that contain DNA. | ||
Those cells regularly wear out and need replacing, which they achieve by dividing into daughter cells. | ||
In fact, the average human body experiences about 10 quadrillion cell divisions in a lifetime! | ||
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When cells divide, their DNA replicates too. | ||
Sometimes during this process mistakes happen and single pieces of DNA get encoded with the incorrect information. | ||
If we compare two strands of DNA and count the differences between them we can see how many mistakes occurred. | ||
This is known as the "Hamming distance". | ||
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We read DNA using the letters C, A, G and T. | ||
Two strands might look like this: | ||
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GAGCCTACTAACGGGAT | ||
CATCGTAATGACGGCCT | ||
^ ^ ^ ^ ^ ^^ | ||
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They have 7 differences, and therefore the Hamming distance is 7. | ||
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The Hamming distance is useful for lots of things in science, not just biology, so it's a nice phrase to be familiar with :) | ||
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## Implementation notes | ||
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The Hamming distance is only defined for sequences of equal length, so an attempt to calculate it between sequences of different lengths should not work. |
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{ | ||
"authors": [ | ||
"keiravillekode" | ||
], | ||
"files": { | ||
"solution": [ | ||
"hamming.s" | ||
], | ||
"test": [ | ||
"hamming_test.c" | ||
], | ||
"example": [ | ||
".meta/example.s" | ||
] | ||
}, | ||
"blurb": "Calculate the Hamming difference between two DNA strands.", | ||
"source": "The Calculating Point Mutations problem at Rosalind", | ||
"source_url": "https://rosalind.info/problems/hamm/" | ||
} |
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.equ UNEQUAL_LENGTHS, -1 | ||
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.text | ||
.globl distance | ||
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/* extern int distance(const char *strand1, const char *strand2); */ | ||
distance: | ||
mov x2, x0 | ||
mov x0, #0 /* distance */ | ||
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.read: | ||
ldrb w3, [x1], #1 /* load byte, with post-increment */ | ||
ldrb w4, [x2], #1 /* load byte, with post-increment */ | ||
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cbz w3, .exit /* check for null terminator */ | ||
cbz w4, .exit | ||
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cmp w3, w4 | ||
cinc x0, x0, ne /* increment distance if characters differ */ | ||
b .read | ||
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.exit: | ||
cmp w3, w4 | ||
beq .return | ||
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mov x0, UNEQUAL_LENGTHS | ||
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.return: | ||
ret |
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# This is an auto-generated file. | ||
# | ||
# Regenerating this file via `configlet sync` will: | ||
# - Recreate every `description` key/value pair | ||
# - Recreate every `reimplements` key/value pair, where they exist in problem-specifications | ||
# - Remove any `include = true` key/value pair (an omitted `include` key implies inclusion) | ||
# - Preserve any other key/value pair | ||
# | ||
# As user-added comments (using the # character) will be removed when this file | ||
# is regenerated, comments can be added via a `comment` key. | ||
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[f6dcb64f-03b0-4b60-81b1-3c9dbf47e887] | ||
description = "empty strands" | ||
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[54681314-eee2-439a-9db0-b0636c656156] | ||
description = "single letter identical strands" | ||
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[294479a3-a4c8-478f-8d63-6209815a827b] | ||
description = "single letter different strands" | ||
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[9aed5f34-5693-4344-9b31-40c692fb5592] | ||
description = "long identical strands" | ||
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[cd2273a5-c576-46c8-a52b-dee251c3e6e5] | ||
description = "long different strands" | ||
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[919f8ef0-b767-4d1b-8516-6379d07fcb28] | ||
description = "disallow first strand longer" | ||
include = false | ||
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[b9228bb1-465f-4141-b40f-1f99812de5a8] | ||
description = "disallow first strand longer" | ||
reimplements = "919f8ef0-b767-4d1b-8516-6379d07fcb28" | ||
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[8a2d4ed0-ead5-4fdd-924d-27c4cf56e60e] | ||
description = "disallow second strand longer" | ||
include = false | ||
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[dab38838-26bb-4fff-acbe-3b0a9bfeba2d] | ||
description = "disallow second strand longer" | ||
reimplements = "8a2d4ed0-ead5-4fdd-924d-27c4cf56e60e" | ||
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[5dce058b-28d4-4ca7-aa64-adfe4e17784c] | ||
description = "disallow left empty strand" | ||
include = false | ||
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[db92e77e-7c72-499d-8fe6-9354d2bfd504] | ||
description = "disallow left empty strand" | ||
include = false | ||
reimplements = "5dce058b-28d4-4ca7-aa64-adfe4e17784c" | ||
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[b764d47c-83ff-4de2-ab10-6cfe4b15c0f3] | ||
description = "disallow empty first strand" | ||
reimplements = "db92e77e-7c72-499d-8fe6-9354d2bfd504" | ||
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[38826d4b-16fb-4639-ac3e-ba027dec8b5f] | ||
description = "disallow right empty strand" | ||
include = false | ||
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[920cd6e3-18f4-4143-b6b8-74270bb8f8a3] | ||
description = "disallow right empty strand" | ||
include = false | ||
reimplements = "38826d4b-16fb-4639-ac3e-ba027dec8b5f" | ||
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[9ab9262f-3521-4191-81f5-0ed184a5aa89] | ||
description = "disallow empty second strand" | ||
reimplements = "920cd6e3-18f4-4143-b6b8-74270bb8f8a3" |
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AS = aarch64-linux-gnu-as | ||
CC = aarch64-linux-gnu-gcc | ||
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CFLAGS = -g -Wall -Wextra -pedantic -Werror | ||
LDFLAGS = | ||
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ALL_LDFLAGS = -pie -Wl,--fatal-warnings | ||
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ALL_CFLAGS = -std=c99 -fPIE $(CFLAGS) | ||
ALL_LDFLAGS += $(LDFLAGS) | ||
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C_OBJS = $(patsubst %.c,%.o,$(wildcard *.c)) | ||
AS_OBJS = $(patsubst %.s,%.o,$(wildcard *.s)) | ||
ALL_OBJS = $(filter-out example.o,$(C_OBJS) $(AS_OBJS) vendor/unity.o) | ||
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CC_CMD = $(CC) $(ALL_CFLAGS) -c -o $@ $< | ||
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all: tests | ||
qemu-aarch64 -L /usr/aarch64-linux-gnu ./$< | ||
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tests: $(ALL_OBJS) | ||
@$(CC) $(ALL_CFLAGS) $(ALL_LDFLAGS) -o $@ $(ALL_OBJS) | ||
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%.o: %.s | ||
@$(AS) -o $@ $< | ||
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%.o: %.c | ||
@$(CC_CMD) | ||
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vendor/unity.o: vendor/unity.c vendor/unity.h vendor/unity_internals.h | ||
@$(CC_CMD) | ||
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clean: | ||
@rm -f *.o vendor/*.o tests | ||
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.PHONY: all clean |
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.equ UNEQUAL_LENGTHS, -1 | ||
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.text | ||
.globl distance | ||
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distance: | ||
ret |
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#include "vendor/unity.h" | ||
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#define UNEQUAL_LENGTHS -1 | ||
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extern int distance(const char *strand1, const char *strand2); | ||
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void setUp(void) { | ||
} | ||
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void tearDown(void) { | ||
} | ||
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void test_empty_strands(void) { | ||
TEST_ASSERT_EQUAL_INT(0, distance("", "")); | ||
} | ||
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void test_single_letter_identical_strands(void) { | ||
TEST_IGNORE(); | ||
TEST_ASSERT_EQUAL_INT(0, distance("A", "A")); | ||
} | ||
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void test_single_letter_different_strands(void) { | ||
TEST_IGNORE(); | ||
TEST_ASSERT_EQUAL_INT(1, distance("G", "T")); | ||
} | ||
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void test_long_identical_strands(void) { | ||
TEST_IGNORE(); | ||
TEST_ASSERT_EQUAL_INT(0, distance("GGACTGAAATCTG", "GGACTGAAATCTG")); | ||
} | ||
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void test_long_different_strands(void) { | ||
TEST_IGNORE(); | ||
TEST_ASSERT_EQUAL_INT(9, distance("GGACGGATTCTG", "AGGACGGATTCT")); | ||
} | ||
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void test_disallow_first_strand_longer(void) { | ||
TEST_IGNORE(); | ||
TEST_ASSERT_EQUAL_INT(UNEQUAL_LENGTHS, distance("AATG", "AAA")); | ||
} | ||
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void test_disallow_second_strand_longer(void) { | ||
TEST_IGNORE(); | ||
TEST_ASSERT_EQUAL_INT(UNEQUAL_LENGTHS, distance("ATA", "AGTG")); | ||
} | ||
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void test_disallow_empty_first_strand(void) { | ||
TEST_IGNORE(); | ||
TEST_ASSERT_EQUAL_INT(UNEQUAL_LENGTHS, distance("", "G")); | ||
} | ||
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void test_disallow_empty_second_strand(void) { | ||
TEST_IGNORE(); | ||
TEST_ASSERT_EQUAL_INT(UNEQUAL_LENGTHS, distance("G", "")); | ||
} | ||
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int main(void) { | ||
UNITY_BEGIN(); | ||
RUN_TEST(test_empty_strands); | ||
RUN_TEST(test_single_letter_identical_strands); | ||
RUN_TEST(test_single_letter_different_strands); | ||
RUN_TEST(test_long_identical_strands); | ||
RUN_TEST(test_long_different_strands); | ||
RUN_TEST(test_disallow_first_strand_longer); | ||
RUN_TEST(test_disallow_second_strand_longer); | ||
RUN_TEST(test_disallow_empty_first_strand); | ||
RUN_TEST(test_disallow_empty_second_strand); | ||
return UNITY_END(); | ||
} |
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